I read this a long time ago, probably as a young teenager, and I loved it. This time around I got a little impatient with the speed of the narrative, which jumps years at a time and then gives lots of details about certain events, and with the constant self-sacrificing of the main character. I suspect that I'm being overly critical, and it's also possible that I'm feeling defensive because I don't give up everything for my kids, like this woman did. So, yeah, it might be guilt, because I live in a time when I can have a family and still do things for myself.
This is a book worth reading, though. You've got the story of the settling of Nebraska and also a life from childhood to old age. There's a lot to think about.